Endocrine Abstracts

Background: Moderate hypophosphatemia is not an uncommon finding. As usually requiring no specific intervention, it might be neglected and serum phosphate measurements are sometimes skipped. Only 1% of phosphorus is in extracellular fluid so it is not a reliable marker of body phosphorus reserve and refractory chronic hypophosphatemia might be a sign of severe phosphorus depletion.Case presentation: A fifty-two-year-old male patient presented with a 12-m...

Background: Bone mineral density measurement sometimes reveals osteoporosis that is a consequence of undiagnosed or neglected long-standing health disorders. These secondary causes of osteoporosis should be carefully investigated, especially in men.Case Presentation: A 63-year-old male complained of back pain and was referred to endocrinology clinic due to a poor densitometry finding indicating osteoporosis. He presented with severe obesity (body mass in...

Background: In March 2020, at the beginning of the first COVID-19 lockdown, Zagreb (Croatia) was hit by a strong earthquake aftermore than 100 years.Restrictive epidemiological measures affected people’s lifestyles, and the earthquakewas an additional traumatic event.Objectives: Determine whether the earthquakes and the lockdown affected glycaemic control in type 1 diabetes patients using flash glucose monitoring (FGM).Metho...

Some hematologic malignancies might increase the risk of fractures due to intrinsic factors of the disease but also because of the treatment with steroids or chemotherapy. The direct impact of novel targeted agents on the development of osteoporosis in these patients has not been recognized yet. A 64-years old female patient with B-cell chronic lymphocytic leukemia (B-CLL) has been followed for four years with no other comorbidities. In order to measure the burden of the disea...

The most common cause of primary hypothyroidism is Hashimoto’s disease, while the most common cause of hyperthyroidism is Graves’ disease; both conditions are autoimmune diseases. In clinical practice, the switch from hypothyroidism to hyperthyroidism is a rare phenomenon. So far, the etiology and mechanisms of conversion have not been determined. We present a case where we believe the monoclonal antibody rituximab was the primary cause of transition. A 58-year-old m...

Background: Several clinical features of chronic liver disease, such as sarcopenia, anaemia, low bone mass and gynecomastia are similar as manifestation of hypogonadism. Decreased testosterone levels are common in patients with severe liver disease and are associated with worse clinical outcomes and mortality.Case Presentation: A 33-year-old patient was admitted to the hospital due to severe alcoholic hepatitis. He was in poor general condition, icteric,...

Background and aims: After two decades of silence in classification system od type 2 diabetes there are some indices that the dibebtic retinopathy might be the sign for introduction of insulin therapy. The aim of this study was to examine associations between measures of diabetic foot in people with diabetes complicated by nonproliferative retinopathy (NPDR), maculopathy and proliferative retinopathy (PDR).Materials and methods: People were included had ...

Primary hyperparathyroidism (PHPT) is nowadays usually diagnosed as an asymptomatic disease but it might be related with advanced end-organ damage. Parathyroid incidentaloma (PI) is the term describing enlarged parathyroid nodules that are unexpectedly discovered on surgery or by imaging performed for nonparathyroid disorders. The recognition of PI might uncover a clinically significant PHPT with the potential for surgical cure. We retrospectively reviewed patients’ reco...

Parathyroid localization by fine needle aspiration and parathyroid hormone (PTH) washout measurement is not a widely accepted method because of possible alterations in parathyroid histology. However, when performed with technical competence this easily available method has been praised to be an immediate confirmation of enlarged parathyroid glands found on ultrasound. We retrospectively reviewed primary hyperparathyroidism (PHPT) patients with previously performed PTH washout ...

Although primary hyperparathyroidism (PHPT) can be successfully cured by parathyroidectomy (PTX) and indications for surgery are well defined, a considerable number of patients do not get operated on. By evaluating referrals for PTX in our academic hospital, we might improve our approach to the care of these patients. We retrospectively reviewed patients’ hospital records with newly diagnosed PHPT between 2014 and 2020. Biochemical and clinical parameters along with resul...